Negative / Null Result ReportOpen accessMedicine

Effects of Intraosseous Tibial vs. Intravenous Vasopressin in a Hypovolemic Cardiac Arrest Model

Justin Fulkerson, MSN; Robert Lowe, BSN; Tristan Anderson, BSN; Heather Moore, BSN; William Craig, DNP, CRNA; Don Johnson, PhD · 2016 · Western Journal of Emergency Medicine

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Introduction: This study compared the effects of vasopressin via tibial intraosseous (IO) and intravenous (IV) routes on maximum plasma concentration (Cmax), the time to maximum concentration (Tmax), return of spontaneous circulation (ROSC), and time to ROSC in a hypovolemic cardiac arrest model. Methods: This study was a randomized prospective, between-subjects experimental design. A computer program randomly assigned 28 Yorkshire swine to one of four groups: IV (n=7), IO tibia (n=7), cardiopulmonary resuscitation (CPR) + defibrillation (n=7), and a control group that received just CPR (n=7).

Abstract by Justin Fulkerson, MSN; Robert Lowe, BSN; Tristan Anderson, BSN; Heather Moore, BSN; William Craig, DNP, CRNA; Don Johnson, PhD, Western Journal of Emergency Medicine (2016) — licensed CC BY 4.0.

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