Replication FailureOpen accessMedicine· cited by 9

AI-based chest X-ray prioritization in the lung cancer diagnostic pathway: the LungIMPACT randomized controlled trial

Nick Woznitza; Lesley Smith; Janette Rawlinson; Iain T H Au-Yong; Bindu George; Madava G. Djearaman; Arjun Nair; Richard W. Lee · 2026 · Nature Medicine

WASTE classifies this as Replication Failure · AI classification, approximate

A previously reported effect did not replicate here — verify it holds before you build on it.

Abstract

Prioritizing artificial intelligence (AI)-detected imaging findings may reduce the time to diagnosis of lung cancer. This prospective, multicentre, randomized controlled trial tested whether immediate AI prioritization of primary care-requested chest X-rays (CXR) influenced time to computed tomography (CT) and lung cancer diagnosis, the primary outcomes. Secondary outcomes included the number of urgent suspected lung cancer referrals, incidence and stage of lung cancer, times to urgent referral and treatment, concordance between AI and radiology reports, and algorithm accuracy. AI was availabl

Abstract by Nick Woznitza; Lesley Smith; Janette Rawlinson; Iain T H Au-Yong; Bindu George; Madava G. Djearaman; Arjun Nair; Richard W. Lee, Nature Medicine (2026) — licensed CC BY 4.0.

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