Antibody drug conjugate targets are highly differentially expressed across the major types of ovarian cancer
Joanna M Porter; Cici Jin; Michael Churchman; Ian Croy; C. Gourley; Oni Glyn-Wright; Marianne C. Stewart; Elizabeth Brownsell · 2025 · European Journal of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Antibody-drug conjugates (ADCs) are emerging anti-cancer agents. The folate receptor alpha (FOLRα)-directed ADC mirvetuximab soravtansine recently demonstrated clinical activity in platinum-resistant ovarian cancer, with other ADCs currently in development. The relative expression of FOLRα and other ADC targets is largely unknown across ovarian cancer histotypes. METHODS: Expression levels of the ADC targets FOLRα, TROP2 and B7-H4 were assessed by immunohistochemistry in patient cohorts using tumour tissue microarrays of the major ovarian cancer histotypes: high grade serous (HGSOC
Abstract by Joanna M Porter; Cici Jin; Michael Churchman; Ian Croy; C. Gourley; Oni Glyn-Wright; Marianne C. Stewart; Elizabeth Brownsell, European Journal of Cancer (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.ejca.2025.115522