Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells
Thi Yen Loan Le; Hilda A. Pickett; Andrian Yang; Joshua W. K. Ho; Sujitha Thavapalachandran; Sindhu Igoor; Sile F. Yang; Melad Farraha · 2019 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
We have previously reported a subpopulation of mesenchymal stromal cells (MSCs) within the platelet-derived growth factor receptor-alpha (PDGFRα)/CD90 co-expressing cardiac interstitial and adventitial cell fraction. Here we further characterise PDGFRα/CD90-expressing cardiac MSCs (PDGFRα + cMSCs) and use human telomerase reverse transcriptase (hTERT) over-expression to increase cMSCs ability to repair the heart after induced myocardial infarction. hTERT over-expression in PDGFRα + cardiac MSCs (hTERT + PDGFRα + cMSCs) modulates cell differentiation, proliferation, survival and angiogenesis re
Abstract by Thi Yen Loan Le; Hilda A. Pickett; Andrian Yang; Joshua W. K. Ho; Sujitha Thavapalachandran; Sindhu Igoor; Sile F. Yang; Melad Farraha, Scientific Reports (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-019-47022-w