A U-shaped association between blood selenium levels and prostate cancer: findings of a case-control study among Nigerian men
Onyinyechi Bede-Ojimadu; Nwakasi Nnamah; Jude A. Onuegbu; Fiorella Barraza; Iain Grant-Weaver; Jideofor Orakwe; Joseph Abiahu; Nkiru Ezeama · 2025 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract The ability of selenium to both prevent and induce cancer at varying biological concentrations has been reported in previous studies. We studied the associations between selenium exposure and prostate diseases such as prostate cancer (PCa) and benign prostatic hyperplasia (BPH), and estimated the optimal range of selenium concentrations that may be needed to prevent these diseases among Nigerian men. Blood and urine samples from men with histologically diagnosed PCa (n = 90), BPH (n = 97), and controls (n = 98) were analyzed for trace elements, including selenium. The associations bet
Abstract by Onyinyechi Bede-Ojimadu; Nwakasi Nnamah; Jude A. Onuegbu; Fiorella Barraza; Iain Grant-Weaver; Jideofor Orakwe; Joseph Abiahu; Nkiru Ezeama, Scientific Reports (2025) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1038/s41598-025-32341-y