Milademetan in Advanced Solid Tumors with MDM2 Amplification and Wild-type TP53: Preclinical and Phase II Clinical Trial Results
Ecaterina E. Dumbrava; Thomas E. Stinchcombe; Mrinal M. Gounder; Gregory M. Coté; Glenn J. Hanna; Bradley Sumrall; Trisha M. Wise‐Draper; Mohammed Kanaan · 2025 · Clinical Cancer Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
PURPOSE: Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that degrades the tumor suppressor p53. In cancers, MDM2 amplification (MDM2amp) leads to overexpression of MDM2, inducing p53 degradation and a p53-null phenotype even in the…
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Metadata source: OpenAlex · DOI 10.1158/1078-0432.ccr-25-0762