Fe(II) with Tris(1-pyrazolyl)methane Complex Increases Thermal Stability In Vitro and Activity In Vivo of the Mutant 447R Form of Mouse Tryptophan Hydroxylase 2.
Terentieva EI; Komleva PD; Antonova SM; Moskaliuk VS; Khotskin NV; Shamshurin MV; Sokolov MN; Kulikov AV · 2026 · International journal of molecular sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Pharmacological chaperones (PCs)-small molecules that normalize the 3D structure of mutant protein molecules-are promising substances for pharmacological treatment of grave hereditary pathologies. In this study, possible chaperone-like…
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Metadata source: Europe PMC · DOI 10.3390/ijms27083411