Simultaneous inhibition of PARP/AKT to intercept nascent BRCA1/2<sup>mut</sup> breast tumors.
Wang L; Sardella BR; Aronson EK; Liu Z; Li X; Wulf GM; Heng YJ · 2026 · NPJ breast cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
We utilized the K14-Cre Brca1 f/f Tp53 f/f mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development.…
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Metadata source: Europe PMC · DOI 10.1038/s41523-026-00892-6