Cathepsins in Neurological Diseases
Dominik Lewandowski; Mateusz Konieczny; Agata Różycka; Krzysztof Chrzanowski; Wojciech Owecki; Jan Kalinowski; Mikołaj Stepura; Paweł P. Jagodzińśki · 2025 · International Journal of Molecular Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Cathepsins, a family of lysosomal proteases, play critical roles in maintaining cellular homeostasis through protein degradation and modulation of immune responses. In the central nervous system (CNS), their functions extend beyond classical proteolysis, influencing neuroinflammation, synaptic remodeling, and neurodegeneration. Emerging evidence underscores the crucial role of microglial cathepsins in the pathophysiology of several neurological disorders. This review synthesizes current knowledge on the involvement of cathepsins in a spectrum of CNS diseases, including Parkinson's disease, Alz
Abstract by Dominik Lewandowski; Mateusz Konieczny; Agata Różycka; Krzysztof Chrzanowski; Wojciech Owecki; Jan Kalinowski; Mikołaj Stepura; Paweł P. Jagodzińśki, International Journal of Molecular Sciences (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ijms26167886