From Framework to Practice: Evaluating the Uptake of Sensitivity Analyses in The National Institute for Health and Care Excellence Real-World External Control Arm Evidence.
Leahy TP; Keenan C; Robertshaw E; McStravick M; Barbier S; Duffield S; Kent S · 2026 · Value in health regional issues
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Objectives Growing reliance on single-arm trials (SATs) is driving increased real-world external control arm (RW-ECA) use in health technology assessment submissions. However, concerns over residual confounding and unmeasured bias often…
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Metadata source: Europe PMC · DOI 10.1016/j.vhri.2026.101651