Durvalumab Plus Olaparib in Previously Untreated, Platinum-Ineligible Patients With Metastatic Urothelial Carcinoma: A Multicenter, Randomized, Phase II Trial (BAYOU)
Jonathan E. Rosenberg; Se Hoon Park; Vadim Kozlov; Tu Van Dao; Daniel Castellano; Jian‐Ri Li; Som D. Mukherjee; Kathryn Howells · 2022 · Journal of Clinical Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
PURPOSE: Homologous recombination repair gene mutations (HRRm) are common in urothelial carcinoma (UC), rendering tumor cells sensitive to poly (ADP-ribose) polymerase (PARP) inhibition. We assessed efficacy and safety of durvalumab…
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Metadata source: OpenAlex · DOI 10.1200/jco.22.00205