Preclinical assessment of leukocyte- and platelet-rich fibrin for inhibition of mandibular osteonecrosis.
Ruocco-Vetucci V; Chaves RAC; Ballan ACF; de Freitas-Alvarenga JC; Mateus T; Dos Santos PL; Cirelli JA; Queiroz TP · 2026 · General dentistry
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Considering that osteonecrosis of the jaw may be due to the antiangiogenic effect of bisphosphonates and that leukocyte- and platelet-rich fibrin (L-PRF) releases proangiogenic factors, this study hypothesized that L-PRF could prevent…
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Metadata source: Europe PMC