Negative / Null Result ReportOpen accessMedicine· cited by 22

DNA Methylation Signatures of Breastfeeding in Buccal Cells Collected in Mid-Childhood

Veronika V. Odintsova; Fiona A. Hagenbeek; Matthew Suderman; Doretta Caramaschi; Catharina E. M. van Beijsterveldt; Noah A. Kallsen; Erik A. Ehli; Davies · 2019 · Nutrients

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Breastfeeding has long-term benefits for children that may be mediated via the epigenome. This pathway has been hypothesized, but the number of empirical studies in humans is small and mostly done by using peripheral blood as the DNA source. We performed an epigenome-wide association study (EWAS) in buccal cells collected around age nine (mean = 9.5) from 1006 twins recruited by the Netherlands Twin Register (NTR). An age-stratified analysis examined if effects attenuate with age (median split at 10 years; n<10 = 517, mean age = 7.9; n>10 = 489, mean age = 11.2). We performed replication

Abstract by Veronika V. Odintsova; Fiona A. Hagenbeek; Matthew Suderman; Doretta Caramaschi; Catharina E. M. van Beijsterveldt; Noah A. Kallsen; Erik A. Ehli; Davies, Nutrients (2019) — licensed CC BY 4.0.

Read the full paper (open access)