The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer’s disease
Lígia Ramos dos Santos; Jucimara Ferreira Figueiredo Almeida; Lúcia Helena Sagrillo Pimassoni; Renato Lírio Morelato; Flavia Paula · 2019 · Genetics and Molecular Biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Genome-wide associations studies (GWAS) are detecting new variants associated with late-onset of Alzheimer's disease (LOAD), a multifactorial neurodegenerative disorder. The variants rs744373 BIN1, rs11136000 CLU and rs3764650 ABCA7 uncovered by GWAS led to different AD pathways, such as metabolism, trafficking and endocytosis of lipids and inflammation. However, most of the association studies did not replicate these variants with significance. This could be due to a small power effect evident when these variants are tested independently with LOAD. Therefore, we aimed to investigate whether t
Abstract by Lígia Ramos dos Santos; Jucimara Ferreira Figueiredo Almeida; Lúcia Helena Sagrillo Pimassoni; Renato Lírio Morelato; Flavia Paula, Genetics and Molecular Biology (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1590/1678-4685-gmb-2018-0320