PPARα activation with fenofibrate confers hippocampal neuroprotection but lacks disease-modifying efficacy in chronic temporal lobe epilepsy.
Zubareva OE; Melik-Kasumov TB; Sinyak DS; Velikoborets GS; Kovalenko AA; Zhabinskaya AA; Kolyhan SA; Korneeva MA · 2026 · Neurochemistry international
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Activation of peroxisome proliferator-activated receptor alpha (PPARα) suppresses neuroinflammation and may interrupt epileptogenesis. We tested whether early intervention with the PPARα agonist fenofibrate exerts disease-modifying effects…
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Metadata source: Europe PMC · DOI 10.1016/j.neuint.2026.106206