Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health
Katherine S. Ruth; Robin N. Beaumont; Jessica Tyrrell; Samuel E. Jones; Marcus A. Tuke; Hanieh Yaghootkar; Andrew R. Wood; Rachel M. Freathy · 2016 · Human Reproduction
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
STUDY QUESTION: How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health? SUMMARY ANSWER: The T allele of the FSHB promoter polymorphism (rs10835638; c.-211G>T) results in longer menstrual cycles and later menopause and, while having detrimental effects on fertility, is protective against endometriosis. WHAT IS KNOWN ALREADY: The FSHB promoter polymorphism (rs10835638; c.-211G>T) affects levels of FSHB transcription and, as a result, circulating levels of FSH. FSH is required for normal fertility and genetic variants at the FSHB locus are as
Abstract by Katherine S. Ruth; Robin N. Beaumont; Jessica Tyrrell; Samuel E. Jones; Marcus A. Tuke; Hanieh Yaghootkar; Andrew R. Wood; Rachel M. Freathy, Human Reproduction (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1093/humrep/dev318