Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202
Valentine Wanga; Charles S. Venuto; Gene D. Morse; Edward P. Acosta; Eric S. Daar; David W. Haas; Chun Li; Bryan E. Shepherd · 2015 · Pharmacogenetics and Genomics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: Tenofovir disoproxil fumarate (TDF) causes kidney toxicity in some patients. We carried out genomewide analyses to identify associations with plasma tenofovir clearance and change in creatinine clearance (CrCl) during the first…
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Metadata source: OpenAlex · DOI 10.1097/fpc.0000000000000156