Randomized controlled trial on the efficacy of topical urea-based cream in preventing capecitabine-associated hand-foot syndrome.
Wongkraisri C; Chusuwanrak K; Laocharoenkeat A; Chularojanamontri L; Nimmannit A; Ithimakin S · 2025 · BMC cancer
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
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Metadata source: Europe PMC · DOI 10.1186/s12885-025-13684-1