Genome‐wide time‐to‐event analysis on smoking progression stages in a family‐based study
Liang He; Janne Pitkäniemi; Kauko Heikkilä; Yi‐Ling Chou; Pamela A. F. Madden; Tellervo Korhonen; Antti‐Pekka Sarin; Samuli Ripatti · 2016 · Brain and Behavior
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Various pivotal stages in smoking behavior can be identified, including initiation, conversion from experimenting to established use, development of tolerance, and cessation. Previous studies have shown high heritability for age of smoking initiation and cessation; however, time-to-event genome-wide association studies aiming to identify underpinning genes that accelerate or delay these transitions are missing to date. METHODS: We investigated which single nucleotide polymorphisms (SNPs) across the whole genome contribute to the hazard ratio of transition between different stages o
Abstract by Liang He; Janne Pitkäniemi; Kauko Heikkilä; Yi‐Ling Chou; Pamela A. F. Madden; Tellervo Korhonen; Antti‐Pekka Sarin; Samuli Ripatti, Brain and Behavior (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/brb3.462