TREM2 in Neurodegenerative Disorders: Mutation Spectrum, Pathophysiology, and Therapeutic Targeting
Hye-Won Yang; Danyeong Kim; YoungSoon Yang; Eva Bagyinszky; Seong Soo A. An · 2025 · International Journal of Molecular Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
TREM2 (triggering receptor expressed on myeloid cells 2) is a membrane-bound receptor primarily expressed on microglia in the central nervous system (CNS). TREM2 plays a crucial role in regulating immune responses, phagocytosis, lipid metabolism, and inflammation. Mutations in the TREM2 gene have been linked to various neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s disease (PD), and Nasu–Hakola disease (NHD). These mutations are suggested to impair microglial activation and reduce the ability to clear amyloid aggregates, leading to ex
Abstract by Hye-Won Yang; Danyeong Kim; YoungSoon Yang; Eva Bagyinszky; Seong Soo A. An, International Journal of Molecular Sciences (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ijms26157057