Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial
Philippa Garety; Clementine Edwards; Hassan Jafari; Richard Emsley; Mark Huckvale; Mar Rus‐Calafell; Miriam Fornells‐Ambrojo; Andrew Gumley · 2024 · Nature Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Distressing voices are a core symptom of psychosis, for which existing treatments are currently suboptimal; as such, new effective treatments for distressing voices are needed. AVATAR therapy involves voice-hearers engaging in a series of facilitated dialogues with a digital embodiment of the distressing voice. This randomized phase 2/3 trial assesses the efficacy of two forms of AVATAR therapy, AVATAR-Brief (AV-BRF) and AVATAR-Extended (AV-EXT), both combined with treatment as usual (TAU) compared to TAU alone, and conducted an intention-to-treat analysis. We recruited 345 participants with p
Abstract by Philippa Garety; Clementine Edwards; Hassan Jafari; Richard Emsley; Mark Huckvale; Mar Rus‐Calafell; Miriam Fornells‐Ambrojo; Andrew Gumley, Nature Medicine (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41591-024-03252-8