Photothermal-driven multifunctional injectable hydrogel platform for promoting diabetic bone defect repair through synergistic immunomodulation and bone homeostasis
Yufan Zhu; Huifan Liu; Zhiqiang Yang; Yaxing He; Ping Wu; Lin Cai; Lufeng Yao; Xiaobin Zhu · 2026 · Theranostics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: Excessive inflammation and exacerbated oxidative stress are significant hallmarks of the diabetic bone microenvironment, which give rise to dysregulated immune reactions and impaired bone homeostasis, thereby hindering bone defect healing and increasing the incidence of bone nonunion.Methods: A biodegradable photothermal hybrid (SC/MTZ) was developed through the in situ self-assembly of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles on tannic acid (TA)-functionalized Ti3C2Tx MXene nanosheets, which were then integrated into a methacrylated silk fibroin/carboxymethyl chitosa
Abstract by Yufan Zhu; Huifan Liu; Zhiqiang Yang; Yaxing He; Ping Wu; Lin Cai; Lufeng Yao; Xiaobin Zhu, Theranostics (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.7150/thno.130240