Polygenic risk scores in routine genetic diagnostics: what lies ahead?
Lauffer P; van Weelden W; van Haelst MM; Jansen PR · 2025 · Journal of community genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Polygenic risk scores (PRS) have emerged as a potential tool for predicting complex genetic traits and disorders, which may complement traditional rare variant testing. As genome-wide association studies (GWAS) expand, PRS predictive…
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Metadata source: Europe PMC · DOI 10.1007/s12687-025-00835-x