Population-based cohort study: proton pump inhibitor use during pregnancy in Sweden and the risk of maternal and neonatal adverse events
Esmee M. Breddels; Johanna Simin; Romina Fornes; Helene Lilja Engstrand; Lars Engstrand; Robin Bruyndonckx; Nele Brusselaers · 2022 · BMC Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Approximately half of all women suffer from heartburn at some stage during pregnancy. The most effective treatment is proton pump inhibitors, but the safety of use during pregnancy cannot be guaranteed. This study aimed to elucidate the effect of proton pump inhibitors on the risk of pre-eclampsia, gestational diabetes mellitus, preterm birth, an Apgar score at 5 min below 7, and a child being small or large for its gestational age. Methods This Swedish population-based study included 1,089,514 live singleton deliveries between July 2006 and December 2016 in Sweden. Multipl
Abstract by Esmee M. Breddels; Johanna Simin; Romina Fornes; Helene Lilja Engstrand; Lars Engstrand; Robin Bruyndonckx; Nele Brusselaers, BMC Medicine (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12916-022-02673-x