Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol.
van de Wetering R; Alder AF; Biggerstaff A; Sellen K; Luo D; Crowley RS; Prisinzano TE; Kivell BM · 2025 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
The development of safer mu opioid receptor (MOR) agonists with reduced side effects is a key focus of pain research. Some studies have suggested that MOR agonists with reduced β-arrestin 2 (βArr2) signaling (i.e. G-protein biased…
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Metadata source: Europe PMC · DOI 10.1038/s41386-025-02214-z