Efficacy and tolerability of valproate versus topiramate in migraine prevention, a randomized controlled multi-center trial.
Zeinhom MG; Elsayed Khalil MF; Omar Youssif TY; Ali Daabis AM; Almoataz M; Refat HM; Mohamed Kamal Ebied AA; Atiaa Mohamed DM · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Although topiramate and valproate are antiseizure medications that have many contraindications and could produce many side effects, they are still used as migraine preventive therapy in middle- and low-income countries. Several trials…
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Metadata source: Europe PMC · DOI 10.1016/j.jocn.2025.111156