Replication of genetic associations of chemotherapy-related cardiotoxicity in the adjuvant NSABP B-31 clinical trial
Pooja Advani; Kathryn J. Ruddy; Joerg Herrmann; Jordan Ray; Emily C. Craver; Greg Yothers; Reena S. Cecchini; Corey Lipchik · 2023 · Frontiers in Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background The cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer agents are well known, but molecular genetic testing is lacking for the early identification of patients at risk for therapy-related cardiac toxicity. Methods Using the Agena Bioscience MassARRAY system, we genotyped TRPC6 rs77679196, BRINP1 rs62568637, LDB2 rs55756123, RAB22A rs707557, intergenic rs4305714, LINC01060 rs7698718, and CBR3 rs1056892 (V244M) (previously associated with either doxorubicin or trastuzumab-related cardiotoxicity in the NCCTG N9831 trial of anthracycline-based chemotherapy ± trastuzum
Abstract by Pooja Advani; Kathryn J. Ruddy; Joerg Herrmann; Jordan Ray; Emily C. Craver; Greg Yothers; Reena S. Cecchini; Corey Lipchik, Frontiers in Oncology (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fonc.2023.1139347