Negative / Null Result ReportOpen accessMedicine· cited by 22

Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients

Minghua Wu; Shervin Assassi; Gloria A. Salazar; Claudia Pedroza; Olga Y. Gorlova; Wei V. Chen; Julio Charles; Miranda L. Taing · 2016 · Arthritis Research & Therapy

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility loci recently identified in the large IIP genome-wide association studies (GWASs) were also risk loci for SSc overall or severity of ILD in SSc. METHODS: A total of 2571 SSc patients and 4500 healthy controls were investigated from the US discovery GWAS and additional US replication cohorts. Thirteen IIP-related selected single nucleotide polymorphisms (SNPs) were genotyped and

Abstract by Minghua Wu; Shervin Assassi; Gloria A. Salazar; Claudia Pedroza; Olga Y. Gorlova; Wei V. Chen; Julio Charles; Miranda L. Taing, Arthritis Research & Therapy (2016) — licensed CC BY 4.0.

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