The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial
Navneet Singh; Stephen J. Hopkins; Sharon Hulme; James Galea; Margaret E. Hoadley; Andy Vail; Peter J. Hutchinson; Samantha Grainger · 2014 · Journal of Neuroinflammation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous (IV) IL-1Ra crosses the blood-brain barrier (BBB) in patients with SAH, to achieve cerebrospinal fluid (CSF) concentrations that are neuroprotective in rats. METHODS: A small phase II, double-blind, randomised controlled study was carried out across two UK neurosurgical centres
Abstract by Navneet Singh; Stephen J. Hopkins; Sharon Hulme; James Galea; Margaret E. Hoadley; Andy Vail; Peter J. Hutchinson; Samantha Grainger, Journal of Neuroinflammation (2014) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1742-2094-11-1