Combination of metronomic oral pazopanib and topotecan for recurrent glioblastoma with and without previous bevacizumab: Results from a phase 2 clinical trial.
Ozer BH; Cohen AL; Colman H; Penas-Prado M; de Groot J; Loghin ME; Pan E; Raizer JJ · 2026 · Neuro-oncology advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Glioblastoma (GBM) has limited effective salvage therapy options. The combination of the Type 1B topoisomerase/HIF1α inhibitor topotecan and the tyrosine kinase inhibitor pazopanib has shown promise in solid tumors and may be…
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Metadata source: Europe PMC · DOI 10.1093/noajnl/vdaf261