Conduction System vs Biventricular Pacing in Heart Failure
André Zimerman; Alexander Dal Forno; Luis E. Rohde; Caique M. Ternes; Fernanda D. Alves; Lucas Petri Damiani; Martino Martinelli-Filho; Roberto Silva Costa · 2026 · JAMA Cardiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Importance: Conduction system pacing (CSP) is a promising and potentially cost-effective alternative to biventricular pacing (BiVP) in patients with heart failure with reduced ejection fraction (HFrEF) and left bundle-branch block (LBBB), but its impact on heart failure (HF) outcomes remains uncertain. Objective: To compare CSP vs BiVP on an HF-related outcome in patients with HFrEF and LBBB. Design, Setting, and Participants: PhysioSync-HF (Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure) was an investigator-initiated, multicenter, noninf
Abstract by André Zimerman; Alexander Dal Forno; Luis E. Rohde; Caique M. Ternes; Fernanda D. Alves; Lucas Petri Damiani; Martino Martinelli-Filho; Roberto Silva Costa, JAMA Cardiology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1001/jamacardio.2026.0101