Immunomodulatory Mechanisms of Chronic Wound Healing: Translational and Clinical Relevance
Mahrukh Riaz; Muhammad Zohaib Iqbal; Agnes S. Klar; Thomas Biedermann · 2025 · MedComm
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Chronic wounds-such as diabetic foot ulcers (DFUs), pressure ulcers (PUs), and venous leg ulcers (VLUs)-pose a serious clinical challenge due to their prolonged inflammatory phase and impaired healing. Increasing evidence reveals that dysregulated immune responses are central to the pathogenesis of chronic wounds. A complex interplay between innate and adaptive immune cells, including macrophages, neutrophils, and T cells, contributes to chronic inflammation, extracellular matrix (ECM) degradation, and tissue repair failure. While current treatments target symptoms, they often overlook the und
Abstract by Mahrukh Riaz; Muhammad Zohaib Iqbal; Agnes S. Klar; Thomas Biedermann, MedComm (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/mco2.70378