Circulating Unmetabolized Folic Acid: Relationship to Folate Status and Effect of Supplementation
Carolyn Tam; Deborah L. O’Connor; Gideon Koren · 2012 · Obstetrics and Gynecology International
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
There are increasing concerns that exposure to unmetabolized folic acid, which results from folic acid intakes that overwhelm the liver's metabolic capacity, may be associated with adverse effects. In this paper, we examined the folic acid status of women of reproductive age in relation to dietary intake and the effect of folic acid supplementation (1.1 mg or 5 mg). Plasma unmetabolized folic acid was not significantly correlated with folate intake estimated by food frequency questionnaire or biomarkers. The proportion of women with detectable levels of unmetabolized folic acid increased from
Abstract by Carolyn Tam; Deborah L. O’Connor; Gideon Koren, Obstetrics and Gynecology International (2012) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1155/2012/485179