Negative / Null Result ReportOpen accessMedicine· cited by 10

Pathogen-specific host response in critically ill patients with blood stream infections: a nested case–control study

Joe M. Butler; Hessel Peters Sengers; Tom D. Y. Reijnders; Tjitske S. R. van Engelen; Fabrice Uhel; Lonneke A. van Vught; Marcus Josephus Schultz; Pierre‐François Laterre · 2025 · EBioMedicine

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: Knowledge of the contribution of the pathogen to the heterogeneity of the host response to infection is limited. We aimed to compare the host response in critically ill patients with a bloodstream infection (BSI). METHODS: RNA profiles were determined in blood obtained between one day before and after a positive blood culture. Differential expression and pathway analyses were performed on independent patients' samples by RNA sequencing (discovery) or microarray (validation). Additional patients were included for the discovery and validation of transcriptome classifiers of pathogen-

Abstract by Joe M. Butler; Hessel Peters Sengers; Tom D. Y. Reijnders; Tjitske S. R. van Engelen; Fabrice Uhel; Lonneke A. van Vught; Marcus Josephus Schultz; Pierre‐François Laterre, EBioMedicine (2025) — licensed CC BY 4.0.

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