No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
Weijie Cao; Xingang Li; Xiaoyu Zhang; Jie Zhang; Qi Sun; Xizhu Xu; Ming Sun; Qiuyue Tian · 2019 · Cells
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches. Methods: Seven single nucleotide polymorphisms (SNPs) were involved as candidate instrumental variables (IVs), summarized from a genome-wide m
Abstract by Weijie Cao; Xingang Li; Xiaoyu Zhang; Jie Zhang; Qi Sun; Xizhu Xu; Ming Sun; Qiuyue Tian, Cells (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/cells8020159