Negative / Null Result ReportOpen accessMedicine· cited by 27

Targeting TREM-1 Signaling in the Presence of Antibiotics is Effective Against Streptococcal Toxic-Shock-Like Syndrome (STSLS) Caused by Streptococcus suis

Chao Yang; Jianqing Zhao; Lan Lin; Shan-Shan Pan; Lei Fu; Li Han; Meilin Jin; Rui Zhou · 2015 · Frontiers in Cellular and Infection Microbiology

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Streptococcus suis (S.suis), a major swine pathogen, is also a severe threat to human health. Infection with highly virulent strains of S. suis can cause human Streptococcal toxic-shock-like syndrome (STSLS), which is associated with high serum pro-inflammatory cytokine levels and a high mortality rate. Our previous study indicated that highly virulent S. suis infection could activate the TREM-1 signaling pathway, which promotes host clearance of S. suis during early infection. However, it remained to be elicited whether TREM-1 signaling could be a target against STSLS in the presence of antib

Abstract by Chao Yang; Jianqing Zhao; Lan Lin; Shan-Shan Pan; Lei Fu; Li Han; Meilin Jin; Rui Zhou, Frontiers in Cellular and Infection Microbiology (2015) — licensed CC BY 4.0.

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