Intermedin inhibits norepinephrine-induced contraction of rat seminal vesicle
P.F. Wong; M.P.L. Cheung; O WS; F. Tang · 2014 · Asian Pacific Journal of Reproduction
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Objective: To study the effect of inter medin(IMD) on smooth muscle of rat seminal vesicles including the specific receptors and the signal pathways involved. Methods: The contraction of the seminal vesicle in response to norepinephrine (NE) and ADM2/IMD was studied by the organ bath method. The effects of antagonists for calcitonin gene related peptide (CGRP), adrenomedullin (ADM) and IMD receptors, and inhibitors of nitric oxide synthase, [L-NG-Nitroarginine Methyl Ester, L-NAME) and cAMP-dependent protein kinase (PKA), KT5720] were also investigated. The first overshoot, amplitude, frequenc
Abstract by P.F. Wong; M.P.L. Cheung; O WS; F. Tang, Asian Pacific Journal of Reproduction (2014) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/s2305-0500(14)60022-1