Eph/Ephrin Profiling in Human Breast Cancer Reveals Significant Associations between Expression Level and Clinical Outcome
Dana M. Brantley‐Sieders; Aixiang Jiang; Krishna Sarma; Akosua Badu-Nkansah; Debra Walter; Yu Shyr; Jin Chen · 2011 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Pre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, however, creating a potential barrier for clinical application. Determining how these observations relate to clinical outcome is a crucial step for translating the biological and mechanistic data into new molecularly targeted therapies. We investigated eph and ephrin expression in human breast cancer relative to endpoints of overall and/or recurrence-f
Abstract by Dana M. Brantley‐Sieders; Aixiang Jiang; Krishna Sarma; Akosua Badu-Nkansah; Debra Walter; Yu Shyr; Jin Chen, PLoS ONE (2011) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0024426