Combined CTLA-4 and PD-L1 blockade in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer is associated with increased myeloid and neutrophil immune subsets in the bone microenvironment
Sumit K. Subudhi; Bilal A. Siddiqui; Ana M. Aparicio; Shalini S. Yadav; Sreyashi Basu; Hong Chen; Sonali Jindal; Rebecca S. Tidwell · 2021 · Journal for ImmunoTherapy of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: Immune checkpoint therapy (ICT) has low response rates in patients with metastatic castration-resistant prostate cancer (mCRPC), in part due to few T cells in the tumor microenvironment (TME). Anti-cytotoxic T…
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Metadata source: OpenAlex · DOI 10.1136/jitc-2021-002919