Bacterial colonization of tumors drives immune activation and checkpoint blockade efficacy.
Rolig AS; Ziglari T; McGee GH; Kasiewicz MJ; Kolbaba K; Simons ND; Pucilowska J; Sfanos K · 2026 · Scientific reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
The tumor microenvironment (TME), which heavily influences immune checkpoint blockade (ICB) efficacy, is shaped by host-microbe interactions. Endogenous intratumoral bacteria have been implicated in efficacy of ICB, such as anti-PD-1…
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Metadata source: Europe PMC · DOI 10.1038/s41598-026-39758-z