Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity
Gary N. Landis; Luke Riggan; Hans S. Bell; William Vu; Tianyi Wang; Ina Wang; Felicia I. Tejawinata; Sebastian Ko · 2022 · Frontiers in Aging
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Mifepristone dramatically increases the life span of mated female Drosophila while reducing the expression of innate immune response genes. Previous results indicated that mifepristone also reduced the load of aero-tolerant bacteria in mated females. Experiments were conducted to further investigate the possible role of bacteria in mifepristone life span effects. Life span was assayed in flies grown from sterilized eggs on autoclaved media and in normally cultured controls in two independent assays. Sterilization increased mated female life span (+8.3% and +57%, respectively), and the effect o
Abstract by Gary N. Landis; Luke Riggan; Hans S. Bell; William Vu; Tianyi Wang; Ina Wang; Felicia I. Tejawinata; Sebastian Ko, Frontiers in Aging (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fragi.2022.924957