Negative / Null Result ReportOpen accessMedicine· cited by 208

Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor

Christoph Garbers; Wolfgang Thaiss; Gareth W. Jones; Georg H. Waetzig; Inken Lorenzen; Florence Guilhot; Rami Lissilaa; Walter Ferlin · 2011 · Journal of Biological Chemistry

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

IL-6 trans-signaling via the soluble IL-6 receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits IL-6 trans-signaling but was described to not interfere with classic signaling via the membrane-bound IL-6R. Physiological and most pathophysiological conditions are characterized by a molar excess of serum sIL-6R over IL-6 characterized by free IL-6 and IL-6 found in IL-6·sIL-6R complexes allowing both classic and trans-signaling. Surprisingly, under these conditions, sgp130 was able to trap all free IL-6 molecules in IL-6·sIL-6R·sg

Abstract by Christoph Garbers; Wolfgang Thaiss; Gareth W. Jones; Georg H. Waetzig; Inken Lorenzen; Florence Guilhot; Rami Lissilaa; Walter Ferlin, Journal of Biological Chemistry (2011) — licensed CC BY 4.0.

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