Dasatinib reduces 5-Fu-triggered apoptosis in colon carcinoma by directly modulating Src-dependent caspase-9 phosphorylation
Yang Fu; Sanfei Peng; Peipei Xue; Zhiqiang Ye; Ge Yang; Luwei Guo; Qiuhong Duan; Yuhan Yin · 2018
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“However, a combination of dasatinib and conventional chemotherapy has failed to show any meaningful outcome in a series of clinical trials.”
Abstract (excerpt)
AbstractPreclinical data have revealed the inhibitory effect of dasatinib on colon cancer. However, a combination of dasatinib and conventional chemotherapy has failed to show any meaningful outcome in a series of clinical trials. We,…
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Metadata source: CORE · DOI 10.1038/s41420-018-0062-5