Translating Pharmacokinetic-Pharmacodynamic Principles Into Improved Methodology for Clinical Trials That Compare Intermittent With Prolonged Infusion of Beta-Lactam Antibiotics.
Tilanus AM; Shields RK; Lodise TP; Drusano GL · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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Abstract (excerpt)
Based on the fact that beta-lactam antibiotics demonstrate time-dependent killing, different dosing strategies have been implemented to increase the time that free (unbound) antibiotic concentrations remain above the minimal inhibitory…
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Metadata source: Europe PMC · DOI 10.1093/cid/ciaf038