Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy
Arshad Khan; Lovepreet K. Mann; Ramesha Papanna; Mi-Ae Lyu; Christopher R. Singh; Scott D. Olson; N. Tony Eissa; Jeffrey D. Cirillo · 2017 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Human mesenchymal stem cells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipoprotein (oxLDL). We report that MSCs phagocytose Mycobacterium tuberculosis (Mtb) through two types of scavenger receptors (SRs; MARCO and SR-B1), as blockade of the receptors with antibodies or siRNA knockdown decreased the uptake of Mtb. MSCs also expressed mannose receptor (MR) that was found to endocytose rhodamine-labeled mannosylated BSA (rMBSA), though the receptor was not involved in the uptake of Mtb. Dil-oxLDL and rMBSA taken up into MSC endosomes colocalized wi
Abstract by Arshad Khan; Lovepreet K. Mann; Ramesha Papanna; Mi-Ae Lyu; Christopher R. Singh; Scott D. Olson; N. Tony Eissa; Jeffrey D. Cirillo, Scientific Reports (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-017-15290-z