Nonopioid vs opioid analgesics after impacted third-molar extractions
Cecile A. Feldman; Janine Fredericks-Younger; Paul J. Desjardins; Hans Malmström; Michael Miloro; Gary Warburton; Brent B. Ward; Vincent B. Ziccardi · 2025 · The Journal of the American Dental Association
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Opioids are still being prescribed to manage acute postsurgical pain. Unnecessary opioid prescriptions can lead to addiction and death, as unused tablets are easily diverted. METHODS: To determine whether combination nonopioid analgesics are at least as good as opioid analgesics, a multisite, double-blind, randomized, stratified, noninferiority comparative effectiveness trial was conducted, which examined patient-centered outcomes after impacted mandibular third-molar extraction surgery. Participants were randomized to receive 5 mg of hydrocodone with 300 mg of acetaminophen (opioi
Abstract by Cecile A. Feldman; Janine Fredericks-Younger; Paul J. Desjardins; Hans Malmström; Michael Miloro; Gary Warburton; Brent B. Ward; Vincent B. Ziccardi, The Journal of the American Dental Association (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.adaj.2024.10.014