Negative / Null Result ReportOpen accessMedicine· cited by 12

Treat-to-Target Urate-Lowering Treatment and Cardiovascular Outcomes in Patients With Gout

Edoardo Cipolletta; Tatiana Zverkova Sandström; D. Rozza; Clémence Leyrat; Georgina Nakafero; P. Drivelegka; A. Avery; Mamas A. Mamas · 2026 · JAMA Internal Medicine

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Importance: Gout is associated with increased cardiovascular risk. Whether achieving a target serum urate level lower than 6 mg/dL with urate-lowering treatment (ULT) would reduce cardiovascular risk in patients with gout is unknown. Objectives: To evaluate the association between achieving a serum urate treatment target lower than 6 mg/dL and cardiovascular events among patients with gout who were newly prescribed ULT. Design, Setting, and Participants: This new-user cohort study using emulated target trial framework with up to 5-year follow-up was performed using primary care data from the C

Abstract by Edoardo Cipolletta; Tatiana Zverkova Sandström; D. Rozza; Clémence Leyrat; Georgina Nakafero; P. Drivelegka; A. Avery; Mamas A. Mamas, JAMA Internal Medicine (2026) — licensed CC BY 4.0.

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