Hepatocyte proliferation assessed by proliferating cell nuclear antigen (PCNA) in relation to age and chemical exposure: Comparison with Ki-67 and mitotic index in the liver micronucleus assay.
Hamada S; Satomoto K; Goto K; Ishikawa Y; Hirochika S; Haruki M; Yamagata H; Takahashi R · 2026 · Mutation research. Genetic toxicology and environmental mutagenesis
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Abstract (excerpt)
Objective The liver micronucleus (MN) assay is useful for detecting genotoxic hepatocarcinogens that may be missed by the erythrocyte MN assay. Because micronuclei form only in dividing cells, evaluating hepatocyte proliferation is…
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Metadata source: Europe PMC · DOI 10.1016/j.mrgentox.2026.503930