Efficacy, Tolerability, and Safety of TRPC4/5 Inhibitor BI 1358894 in Patients With Major Depressive Disorder and Inadequate Response to Antidepressants: A Phase 2 Randomized, Placebo-Controlled, Parallel Group, Dose-Ranging Trial.
Shelton RC; Pizzagalli DA; Cohen EA; Hori H; Dickschat U; Asafu-Adjei J; Feldbarg A; Just S · 2025 · The Journal of clinical psychiatry
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
Objective: To assess proof-of-concept (PoC) for efficacy, tolerability, and safety of TRPC4/5 inhibitor BI 1358894 vs placebo in patients with major depressive disorder (MDD) with inadequate response to ongoing antidepressants. Methods: In…
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Metadata source: Europe PMC · DOI 10.4088/jcp.25m15868