Gentamicin triggers fatty acid oxidation-dependent mitochondrial ROS, driving greater nephrotoxicity than apramycin and other aminoglycosides.
Liepinsh E; Krims-Dāvis K; Cirule H; Pinkovskis K; Ozola M; Sevostjanovs E; Makrecka-Kuka M; Dambrova M · 2026 · Free radical biology & medicine
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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Abstract (excerpt)
Apramycin has emerged as a promising antibacterial drug candidate that has demonstrated great preclinical efficacy and safety profile. In comparative studies, apramycin was found to be significantly less nephrotoxic than gentamicin;…
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Metadata source: Europe PMC · DOI 10.1016/j.freeradbiomed.2026.06.042